Thymulin

Thymulin (formerly Facteur Thymique Sérique, FTS) is a naturally occurring thymic nonapeptide first characterized by Bach and Dardenne in 1977. Unlike most peptides, Thymulin is biologically active only when complexed with zinc — the zinc-bound form (Thymulin-Zn) binds to T-cell receptors and promotes T-cell differentiation, maturation, and cytokine production. Thymulin is produced by thymic epithelial cells and circulates in the blood bound to a carrier protein. Its serum concentration declines sharply with age in parallel with thymic involution — from peak levels in childhood to near-undetectable levels in elderly adults. This age-related decline has made Thymulin a focus of immune-aging research, with the hypothesis that restoring Thymulin levels could partially reverse age-related immune decline. Studies have also investigated Thymulin for anti-inflammatory effects, neuroprotection, and modulation of neuroimmune interactions.

Reconstitution

Reconstitute with bacteriostatic water. Store refrigerated. Activity requires zinc — supplement with zinc-containing solutions or ensure adequate zinc status.