TB-500 Fragment 17-23
Research OnlyEarly EvidenceTB-500 Fragment 17-23 (Thymosin Beta-4 Fragment)
The minimal active fragment of Thymosin Beta-4 — a heptapeptide spanning residues 17–23 that retains the actin-binding and pro-healing properties of full TB-500 at a fraction of the molecular weight.
Half-Life
Short — estimated < 1 hour
Molecular Weight
726.8 g/mol
TB-500 Fragment 17-23 is a synthetic heptapeptide corresponding to residues 17 through 23 of the full Thymosin Beta-4 (TB-500) sequence. It contains the actin-binding motif LKKTET (adjacent to this fragment) and represents the minimal sequence required for many of TB-500's biological activities. Research with the full TB-500 molecule identified this region as critical for G-actin sequestration, cell migration, and wound healing. The fragment is substantially smaller than full TB-500 (727 Da vs ~4963 Da), which may affect tissue distribution and half-life. Preclinical studies suggest it retains anti-inflammatory, pro-healing, and angiogenic properties. Vendors market it as a more cost-effective alternative to full-length TB-500, though comparative clinical data is absent. It is considerably less well-studied than the full molecule.
Also Known As
Amino Acid Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-NH2
Reconstitution
Reconstitute with bacteriostatic water. Store refrigerated. Shorter half-life than full TB-500 — more frequent dosing may be required.
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