Sermorelin
Not ApprovedStrong EvidenceSermorelin Acetate
A synthetic analog of GHRH that stimulates natural growth hormone release — one of the most studied GH secretagogues.
Half-Life
~10–20 minutes
Molecular Weight
3357.9 g/mol
Sermorelin is a synthetic 29-amino-acid analog of endogenous growth hormone-releasing hormone (GHRH). It was FDA-approved for pediatric GH deficiency diagnosis in the 1990s (withdrawn from US market in 2008 for commercial, not safety, reasons). Sermorelin stimulates the pituitary to produce GH in a physiological, pulsatile manner — preserving the body's natural feedback regulation. This makes it mechanistically distinct from and often considered safer than exogenous GH administration. It remains widely used in anti-aging and wellness medicine.
Also Known As
Amino Acid Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Reconstitution
Reconstitute with bacteriostatic water. Typical concentration: 1 mg/mL.
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