Semax

Semax is a synthetic heptapeptide derived from the ACTH 4-7 fragment (Met-Glu-His-Phe), extended with a Pro-Gly-Pro sequence for metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it is approved in Russia and Ukraine as a nootropic and neuroprotective agent. Unlike standard ACTH analogs, semax lacks hormonal activity (no cortisol stimulation) but retains and enhances the peptide's neurotrophic and cognitive-enhancing properties. It significantly upregulates BDNF and activates serotonergic, dopaminergic, and cholinergic systems. Russian clinical use includes stroke rehabilitation, traumatic brain injury, and cognitive enhancement.

Reconstitution

Available as nasal drops in Russia. Research peptide: reconstitute in sterile saline for intranasal use (typical: 0.1% solution).