Selank
Research OnlyModerate EvidenceSelank (TP-7)
A synthetic analog of the endogenous immunomodulatory tetrapeptide Tuftsin, studied for anxiolytic, nootropic, and immune-enhancing effects.
A synthetic peptide developed by Russian scientists based on a natural immune peptide called Tuftsin. Studied for anxiety reduction and mild cognitive enhancement, with a calming effect that doesn't produce sedation or dependence — distinct from benzodiazepines in both mechanism and risk profile.
Half-Life
~2 minutes (endogenous Tuftsin); selank ~5 minutes
Molecular Weight
751.8 g/mol
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg), developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. By extending Tuftsin with a stabilizing Pro-Gly-Pro sequence, selank achieves significantly greater metabolic stability. It is widely used in Russia as an anxiolytic and nootropic agent. Unlike benzodiazepines, selank modulates the GABA-A system without producing sedation, tolerance, or dependence. It also demonstrates notable immune-enhancing effects and has been studied for stress-induced immunosuppression.
Also Known As
Amino Acid Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Reconstitution
Available as nasal spray in Russian clinical settings. Research peptide: reconstitute with sterile saline for intranasal use.
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