MOTS-c
Research OnlyEarly EvidenceMitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondrial-derived peptide that regulates metabolic homeostasis, insulin sensitivity, and exercise capacity.
Half-Life
Not well established
Molecular Weight
2174.5 g/mol
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome — specifically the 12S ribosomal RNA gene. Discovered in 2015 by researchers at USC, it represents a new class of mitochondrial-derived peptides (MDPs) that regulate systemic metabolic function. MOTS-c acts as a retrograde signal from mitochondria to the nucleus, regulating gene expression involved in glucose metabolism, fatty acid oxidation, and insulin sensitivity. Circulating MOTS-c levels decline with age and in metabolic disease, positioning it as a potential therapeutic target for age-related metabolic decline. It has demonstrated remarkable exercise-mimicking effects in rodent models.
Also Known As
Amino Acid Sequence
Tyr-Arg-Trp-Leu-Thr-Met-Pro-Gln-Arg-Asn-Ser-Val-Ser-Arg-Thr-Arg-Ala-Ala-Val-Arg-Asp-Gly-Ile-Ser-His-Ala-Arg-His-Val-Arg
Reconstitution
Reconstitute with bacteriostatic water. Typical concentration: 5 mg/mL.
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