LL-37
Research OnlyModerate EvidenceCathelicidin Antimicrobial Peptide LL-37
The only known human cathelicidin — a multifunctional antimicrobial peptide with immune modulation, wound healing, and anti-biofilm activity.
The only cathelicidin (antimicrobial peptide) naturally produced by humans. Released by immune cells at sites of infection or injury, it kills bacteria, viruses, and fungi directly while also modulating the inflammatory response and promoting tissue repair — a dual role as both antimicrobial and healing agent.
Half-Life
~30 minutes
Molecular Weight
4493.4 g/mol
LL-37 is the only member of the cathelicidin family of antimicrobial peptides expressed in humans. It is derived from the C-terminal cleavage of the precursor protein hCAP18, which is stored in neutrophil granules and secreted by epithelial cells in response to infection or injury. LL-37 kills bacteria by disrupting their membranes while simultaneously modulating the host immune response — promoting wound healing, angiogenesis, and suppressing excessive inflammation. Its activity against biofilm-forming bacteria, including antibiotic-resistant strains, has generated significant interest as a novel anti-infective. LL-37 levels are reduced in patients with chronic wounds, atopic dermatitis, and certain infections.
Also Known As
Amino Acid Sequence
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Reconstitution
Reconstitute with sterile saline. Use fresh — LL-37 is susceptible to proteolytic degradation.
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