LL-37
Research OnlyModerate EvidenceCathelicidin Antimicrobial Peptide LL-37
The only known human cathelicidin — a multifunctional antimicrobial peptide with immune modulation, wound healing, and anti-biofilm activity.
Half-Life
~30 minutes
Molecular Weight
4493.4 g/mol
LL-37 is the only member of the cathelicidin family of antimicrobial peptides expressed in humans. It is derived from the C-terminal cleavage of the precursor protein hCAP18, which is stored in neutrophil granules and secreted by epithelial cells in response to infection or injury. LL-37 kills bacteria by disrupting their membranes while simultaneously modulating the host immune response — promoting wound healing, angiogenesis, and suppressing excessive inflammation. Its activity against biofilm-forming bacteria, including antibiotic-resistant strains, has generated significant interest as a novel anti-infective. LL-37 levels are reduced in patients with chronic wounds, atopic dermatitis, and certain infections.
Also Known As
Amino Acid Sequence
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Reconstitution
Reconstitute with sterile saline. Use fresh — LL-37 is susceptible to proteolytic degradation.
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