Kisspeptin-10

Kisspeptin-10 is the biologically active C-terminal decapeptide of kisspeptin (also called metastin), encoded by the KISS1 gene. Kisspeptin acts as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, binding the KISS1R receptor (GPR54) to trigger pulsatile GnRH secretion, which in turn stimulates LH and FSH release. It is essential for puberty onset and reproductive function — loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism. Kisspeptin-10 is the shortest active fragment, retaining full KISS1R binding activity while being the most feasible for therapeutic use. Clinical applications include fertility treatment and the diagnosis and management of hypogonadism.

Reconstitution

Reconstitute with sterile saline. Very potent — accurate dosing requires precise dilution.