Humanin

Humanin is a 21-amino-acid peptide encoded in the 16S ribosomal RNA region of the mitochondrial genome, discovered in 2001 in a screen for factors that protect neurons against Alzheimer's disease-associated toxicity. Like MOTS-c, it represents the class of mitochondrial-derived peptides (MDPs) — retrograde signals from mitochondria that regulate systemic physiology. Circulating humanin levels decline with age and in multiple disease states. It protects neurons and cardiomyocytes against apoptosis, reduces insulin resistance, and has anti-inflammatory properties. HNG (S14G-Humanin), in which serine at position 14 is substituted with glycine, is approximately 1000x more potent than native humanin and is the form typically used in research.

Reconstitution

Reconstitute with bacteriostatic water. HNG (S14G-Humanin) is used at much lower doses than native humanin.