Semaglutide
FDA ApprovedStrong EvidenceSemaglutide (Ozempic / Wegovy)
An FDA-approved GLP-1 receptor agonist with the strongest weight-loss and cardiovascular trial data of any compound sold by peptide vendors — and the only one that is a regulated pharmaceutical.
The most powerful weight-loss and cardiovascular risk drug available as of 2026, and the only one on this platform that's actually FDA-approved as a prescription medication. It works by mimicking a gut hormone that tells your brain you're full, slows digestion, and protects the heart through multiple pathways. The Phase 3 trials are among the most rigorous in drug history — ~15% body weight loss sustained for 2 years is a genuinely remarkable result. The catches: GI side effects are common (though usually manageable), weight comes back rapidly when you stop, and vendors selling it without prescriptions are operating outside pharmaceutical regulations with no guarantee of the product's actual quality.
Half-Life
~7 days (subcutaneous); enables once-weekly dosing
Molecular Weight
4113.58 g/mol
Semaglutide is a synthetic GLP-1 receptor agonist engineered from the 26 amino acid GLP-1(7-37) sequence with two modifications: amino acid substitution at position 8 (Ala→Aib) blocks DPP-4 degradation, and a C18 fatty diacid chain via a linker at lysine 26 enables albumin binding — extending half-life from 2 minutes (native GLP-1) to approximately 7 days. This enables once-weekly subcutaneous dosing (Ozempic for T2D, Wegovy for obesity) or once-daily oral dosing (Rybelsus). It is FDA-approved for three indications: type 2 diabetes (2017), chronic weight management (2021), and cardiovascular risk reduction in obese/overweight adults (2023 post SELECT trial). **Semaglutide is a regulated pharmaceutical drug, not a research chemical.** Its presence in the peptide vendor market is legally and medically distinct from other peptides on this platform — vendors selling it without a prescription are operating outside pharmaceutical regulations.
Also Known As
Amino Acid Sequence
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 fatty diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-NH₂
Reconstitution
FDA-approved versions are pre-filled pens. Research peptide: reconstitute with bacteriostatic water; start with low concentration (0.5 mg/mL) for dose precision.
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