hGH Fragment 176-191
Research OnlyModerate EvidenceHuman Growth Hormone Fragment 176-191
The C-terminal lipolytic fragment of human growth hormone — isolated fat-burning activity without GH's growth-promoting or insulin-disrupting effects.
Half-Life
~30 minutes
Molecular Weight
1817.1 g/mol
hGH Fragment 176-191 is the C-terminal 16-amino-acid segment of human growth hormone (hGH), corresponding to the same region modified in AOD-9604. The key structural difference: AOD-9604 has an N-terminal tyrosine substituted with a modified residue for improved stability, while Fragment 176-191 is the unmodified native sequence. Both act through similar beta-3 adrenergic receptor mechanisms to promote lipolysis, but AOD-9604 is generally considered more stable and potent. Fragment 176-191 has been studied in obese rodents and human cell cultures as a mechanism for isolating GH's fat-burning activity from its growth-promoting (and insulin-disrupting) effects.
Also Known As
Amino Acid Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-NH2
Reconstitution
Reconstitute with bacteriostatic water. Typical concentration: 1 mg/mL.
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