DSIP
Research OnlyEarly EvidenceDelta Sleep-Inducing Peptide (DSIP)
A naturally occurring nonapeptide originally isolated from rabbit cerebral venous blood during sleep — researched for sleep regulation, stress adaptation, and anti-aging properties.
A neuropeptide originally isolated from rabbit cerebrospinal fluid that was found to induce slow-wave sleep when injected into animals. Also studied for stress regulation, cortisol modulation, and withdrawal support — though its sleep-inducing effects in humans are less consistent than the original animal findings suggested.
Half-Life
~20–30 minutes
Molecular Weight
848.9 g/mol
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated in 1977 by Schoenenberger and Monnier from the cerebral venous blood of rabbits in slow-wave sleep. It is found endogenously in the hypothalamus, pituitary, and peripheral tissues. DSIP has been studied for its effects on sleep architecture, GH release, cortisol regulation, and stress adaptation. Despite its name, DSIP does not consistently induce sleep in all experimental conditions — its effects on sleep appear to be modulatory rather than sedative. Russian research (Khavinson group) has investigated DSIP as an anti-aging bioregulator. Clinical data is limited; most evidence is from small trials or preclinical work. It remains of interest in longevity research for its endocrine-modulating and stress-buffering properties.
Also Known As
Amino Acid Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Reconstitution
Reconstitute with bacteriostatic water at 0.5–1 mg/mL. Store refrigerated. Use within 30 days.
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