CJC-1295 with DAC
Research OnlyModerate EvidenceCJC-1295 with Drug Affinity Complex (DAC)
A long-acting GHRH analog with a maleimide-lysine DAC modification that covalently binds albumin — extending half-life to ~8 days and producing sustained GH elevation instead of physiological pulses.
CJC-1295 with a chemical attachment — the Drug Affinity Complex (DAC) — that hooks it to albumin in the blood, extending its active duration from ~30 minutes to approximately 6–8 days. Unlike CJC-1295 without DAC, which produces brief GH pulses, this version produces a continuous low-level GH elevation throughout the week — a fundamentally different effect.
Half-Life
~6–8 days
Molecular Weight
3647.3 g/mol
CJC-1295 with DAC (Drug Affinity Complex) is a GHRH analog that incorporates a lysine-maleimide DAC modification allowing covalent binding to circulating albumin. This binding extends its half-life to approximately 6–8 days, enabling once- or twice-weekly dosing. Unlike CJC-1295 without DAC (which produces pulsatile GH release when combined with a GHRP), CJC-1295 DAC produces sustained, elevated GH and IGF-1 levels throughout the week — a 'GH bleed' rather than discrete pulses. This distinction is important: continuous GH elevation mimics the pharmacology of exogenous GH more than physiological GH secretion, raising questions about receptor desensitization and differing risk profiles.
Also Known As
Amino Acid Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(maleimidopropionate)-NH2
Reconstitution
Reconstitute with bacteriostatic water. Typical concentration: 1–2 mg/mL.
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